Receptor Autoradiography
For autoradiography, we apply a phosphor screen apposed to a radioactive tissue section to give an image of the radiolabeled probe with our Fuji phosphorimagers, or radioactive disintegrations are detected in real-time with our BetaIMAGERs™. The radiolabeled probe can be applied to the tissue either in vitro, in vivo or ex vivo.
Autoradiography can be used to determine in tissue sections:
Receptor Occupancy Autoradiography
Receptor occupancy determinations of a competing unlabeled drug given either in vitro, in vivo or ex vivo.
Quantitative Whole Body Autoradiography
in vivo ADME studies are an important component of the drug development process which is designed to investigate the Absorption, Distribution, Metabolism, and Excretion (ADME) of your novel compounds.
![Autoradiographic analysis of [3H]MK-801 (dizocilpine) in vitro binding to NMDA receptors in rodent brain tissue](http://metislabs.com/wp-content/uploads/2019/05/MK801-RGB-1-222x300.jpg "Bidning of NMDA Receptors using [3H] MK801")
in vitro Receptor Distribution Autoradiography
in vitro Anatomical distribution (receptor distribution) of binding sites of a radiolabeled or non-radiolabeled drug.
Functional Autoradiography [35S]-GTPγS
[35S]-GTPγS autoradiography reveals distribution and functional activation of GPCR receptors.