Dopamine Receptor Radiochemicals


Dopamine Receptors are a class of G protein-coupled receptors (GPCRs) that are prominent in the mammalian central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine is the major catecholamine neurotransmitter and is responsible for a variety of functions, including locomotion, neuroendocrine secretion, cognition and emotion. It also plays a role in the periphery where it regulates a range of other processes, including catecholamine release, hormone secretion, and gastrointestinal motility.

There are five dopamine receptor sub-types divided into D1-like (D1 & D5) and D2-like (D2, D3 & D4) based on their predicted transmembrane topologies, and functional and pharmacological properties. Dysregulation of dopamine transmission causes a variety of conditions such as Parkinson’s disease, Tourette’s syndrome, schizophrenia and hyperprolactemia.

Important: To receive radiochemicals please submit your Department of Health Radioactive Materials License to (or fax to: 516.825.5129, ATTN Rad Support) to ensure rapid receipt of your radiochemical order.