SB 674042, [Methoxy-3H]-          *EXCLUSIVE*   

Catalog>7TM>Peptide>OX>[3H]SB 674042


Product Number: NML3H1017
Alternate Name: NA
Specific Activity: 46-51 Ci/mmol
1.7-1.9 TBq/mmol
CAS Number (Parent): 483313-22-0
Shipping Conditions: Shipped on dry ice
Storage Conditions: -20ºC, in ethanol

Information:  Potent & selective non-peptide Orexin OXreceptor antagonist radioligand. Exhibits 100-fold selectivity for OX1 over OX2 receptors.  Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors.  

Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: Comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2- sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA)
P. Malherbe, O. Roche, A. Marcuz, C. Kratzeisen, J. G. Wettstein, and C. Bissantz (2010) Molecular Pharmacology 78:81–93. PMID: 20404073

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