Receptor Autoradiography

For autoradiography, we apply a phosphor screen apposed to a radioactive tissue section to give an image of the radiolabeled probe with our Fuji phosphorimagers, or radioactive disintegrations are detected in real-time with our BetaIMAGERs™. The radiolabeled probe can be applied to the tissue either in vitro, in vivo or ex vivo.

Autoradiography can be used to determine in tissue sections:

Receptor Occupancy Autoradiography

Receptor occupancy determinations of a competing unlabeled drug given either in vitro, in vivo or ex vivo.

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Quantitative Whole Body Autoradiography

in vivo ADME studies are an important component of the drug development process which is designed to investigate the AbsorptionDistributionMetabolism, and Excretion (ADME) of your novel compounds.

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in vitro Receptor Distribution Autoradiography

in vitro Anatomical distribution (receptor distribution) of binding sites of a radiolabeled or non-radiolabeled drug.

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Functional Autoradiography [35S]-GTPγS

[35S]-GTPγS autoradiography reveals distribution and functional activation of GPCR receptors.

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