Metabotropic Glutamate Receptor Radiochemicals

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Metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are are coupled to a variety of second messenger systems via G-protein coupled receptors (GPCRs). Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter. Eight different mGluR subtypes (mGluR1-8) have been cloned.

These receptors have been classified into 3 groups based on amino acid sequence similarity, agonist pharmacology and the signal transduction pathways to which they couple. Group I mGluRs (mGluR1 and mGluR5) stimulate inositol phosphate metabolism and mobilization of intracellular Ca2+, whereas group II (mGluR2 and mGluR3) and group III (mGluR4 and mGluR6-8) couple to adenylyl cyclase.

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