Metabotropic Glutamate Receptor Radiochemicals


Metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are are coupled to a variety of second messenger systems via G-protein coupled receptors (GPCRs). Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter. Eight different mGluR subtypes (mGluR1-8) have been cloned.

These receptors have been classified into 3 groups based on amino acid sequence similarity, agonist pharmacology and the signal transduction pathways to which they couple. Group I mGluRs (mGluR1 and mGluR5) stimulate inositol phosphate metabolism and mobilization of intracellular Ca2+, whereas group II (mGluR2 and mGluR3) and group III (mGluR4 and mGluR6-8) couple to adenylyl cyclase.

LY341495 Cat Button

MMTEP Cat Button

Important: To receive radiochemicals please submit your Department of Health Radioactive Materials License to (or fax to: 516.825.5129, ATTN Rad Support) to ensure rapid receipt of your radiochemical order.